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class="Serp__item__snippet--34vQF">Pharmacology of Advil, Motrin (ibuprofen). Mechanism of action. Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclo-oxygenase (COX) isoenzymes, COX-1 and COX-2. May inhibit chemotaxis, alter lymphocyte activity, decrease...